(PDF) Regulatory T Cells in Health and Disease Vol 136 By Adrian Liston

This is the PDF eBook version for Regulatory T Cells in Health and Disease Vol 136 By Adrian Liston

Table of Contents

Preface
Chapter One: Transcriptional and Epigenetic Control of Regulatory T Cell Development
Abstract
1 Introduction
2 Transcriptional Regulation in Treg Cells
3 Epigenetic Regulation in Treg Cells
4 Cross talk Between Foxp3-Dependent Gene Regulation and Treg Cell-Type Epigenetic Modifications
5 Treg Cell Development
6 Conclusion
Acknowledgment
Chapter Two: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells
Abstract
1 Introduction: Key Treg Characteristics
2 Peripheral De Novo Induction of Foxp3 Tregs Within the Gastrointestinal Immune System
3 Outlook
Chapter Three: Understanding the Roles of the NF-?B Pathway in Regulatory T Cell Development, Differentiation and Function
Abstract
1 Introduction
2 NF-?B and Treg Development
3 NF-?B Involvement in Treg Function
4 Conclusion
Chapter Four: The Molecular Control of Regulatory T Cell Induction
Abstract
1 Introduction
2 Treg Differentiation in the Thymus
3 Peripheral Treg
4 Concluding Remarks
Acknowledgments
Chapter Five: The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells
Abstract
1 T Helper 17 Cells
2 Th17 Cells and Treg Cells: A Special Relationship
3 Concluding Remarks
Acknowledgments
Chapter Six: Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
Abstract
1 Of Mice and Men: An Historical Perspective on Tregs
2 Immunosuppressive Mechanisms of Tregs
3 Tregs Impair DC Function
4 Concluding Remarks
Chapter Seven: Development and Function of Effector Regulatory T Cells
Abstract
1 Introduction
2 Features of Effector T Regulatory Cells
3 Role of TCR Signaling in Effector T Regulatory Cell Differentiation
4 Cytokine Requirements of Effector T Regulatory Cells
5 Distinct Migratory Properties of Effector T Regulatory Cells
6 Functional Specialization of Effector T Regulatory Cells
7 Effector T Regulatory Cells in Nonlymphoid Organs
8 A Unified Model of Effector T Regulatory Cell Differentiation
9 Future Perspectives
Acknowledgments
Chapter Eight: Treg Cell Differentiation: From Thymus to Peripheral Tissue
Abstract
1 Introduction
2 Thymic Treg Cells
3 Further Differentiation of Treg Cells in the Periphery
4 Future Perspectives
Acknowledgments
Chapter Nine: Regulatory T cells in Arthritis
Abstract
1 Introduction
2 Treg Cells in the Inflammation That Occurs in RA
3 Treg Cells in the Bone Destruction in RA
4 The Plasticity of Foxp3 T Cell in Arthritis
5 Treg Cell-Targeted Therapies Against RA
6 Conclusions
Acknowledgment
Chapter Ten: The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection
Abstract
1 Introduction
2 Acute Infections in Delicate Tissues
3 Acute Systemic Viral Infections
4 Gastrointestinal Infections
5 Chronic Infections
6 Conclusions and Future Directions
Chapter Eleven: Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential
Abstract
1 Introduction
2 Sites of Treg Action in T1D
3 Mechanisms of Treg Suppression in T1D
4 Therapeutic Manipulation of Treg in T1D
5 Concluding Remarks
Acknowledgments
Index