(PDF) Development of T Cell Immunity Volume 92 By Adrian Liston

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Table of Contents

Contributors
The Development of T-Cell Immunity
Genome Duplication and T Cell Immunity
I. Introduction
II. WGD: From a Hypothesis to the Fact
III. Roles of Ohnologs in Adaptive Immunity
IV. Controversies Surrounding the Timing of WGD
V. The AIS of Jawless Vertebrates
VI. Concluding Remarks
Acknowledgments
The Origin and Role of MHC Class I-Associated Self-Peptides
I. Key Features of the Adaptive Immune System
II. Genesis of the SMII
III. The Role of Constitutive Self-Peptide Presentation
Acknowledgments
Functional Development of the T Cell Receptor for Antigen
I. Introduction
II. TCR Structure and Diversity
III. Thymic Self-Peptides Involved in T Cell Selection
IV. Synaptic and Nonsynaptic Interactions in the Thymus
V. miR-181a, A MicroRNA That Enhances T Cell Sensitivity and Promotes Tolerance
VI. The Selecting Ligand and the Purpose of Selection
VII. On the Role of Self-Peptides in the Activation of CD4 Versus CD8 T Cells
VIII. Conclusions
Transcriptional Regulation of Thymus Organogenesis and Thymic Epithelial Cell Differentiation
I. Introduction
II. Transcription Factors Controlling Organ Patterning and Initial Organogenesis
III. Patterning Events Lead to Induction of the Thymus-Specific Transcription Factor Foxn1
IV. NF?b Pathway and Medullary Formation
V. Future Directions
Early T Cell Differentiation
I. Introduction
II. Oncogenic Transcription Factors
III. Signal Transduction Pathways
IV. Tumor Suppressors
V. Concluding Remarks
Acknowledgments
Lymphoid Tissue Inducer Cells and the Evolution of CD4 Dependent High-Affinity Antibody Responses
I. Introduction
II. LTi and the Development of Organized Lymphoid Structures
III. LTi Express Recently Evolved Tumor Necrosis Family Member Ligands
IV. High-Affinity Class Switched Antibodies Depend on LTa and LTß Induced Organization
V. AID-Dependent Class Switching Anticipated Affinity Maturation and CD4 Memory Antibody Responses
VI. The Genes for Organization Show Linkage with CD4 and AID
VII. OX40L and CD30L are Expressed by LTi
VIII. Lack of CD4 Memory in Mice Deficient in OX40 and CD30
IX. CD30-Signals Evolved Before OX40 and the LTßR, and Share Functions in Both Organization and CD4 Memory
X. Direct Evidence that LTI are Required for CD4 Memory
XI. LTi and the Induction and Maintenance of Tolerance
XII. Putative Origin of LTi and Summary
Acknowledgments
Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development
I. Foreword
II. Historical Perspective: Lymphoid Tissue Development, 1836–1996
III. Tools and Technologies Transforming Analysis of Lymphoid Tissue Development
IV. 1996 Onward: Requirements for Lymph Node and Peyer’s Patch Development
T Follicular Helper Cells During Immunity and Tolerance
I. Introduction
II. T-Dependent Antibody Responses
III. Germinal Center-Derived Autoimmunity
IV. Germinal Center Tolerance
V. T Follicular Helper Cells
VI. Tfh Cells Mediate Selection of Germinal Center B Cells
VII. Breaks in Tfh Tolerance Result in Autoimmunity
VIII. Tolerizing Tfh Cells
IX. Concluding Remarks
Thymic Selection and Lineage Commitment of CD4 Foxp3 Regulatory T Lymphocytes
I. Introduction
II. The Treg-Repertoire
III. Thymic Selection of the Treg-Repertoire
IV. Thymic Commitment to the Treg-Lineage
V. Concluding Remarks
Is Foxp3 the Master Regulator of Regulatory T Cells?
Questions Arising from “Genome Duplication and T Cell Immunity”
Response to Questions
I. Response to Question #1
II. Response to Question #2
Questions Arising from “The Origin and Role of MHC Class I-Associated Self-Peptides”
Response to Questions
I. Response to Question #1
II. Response to Question #2
Commentary on “Lymphoid Tissue Inducer Cells and the Evolution of CD4 Dependent High-Affin