(PDF) Antibiotics – Challenges, Mechanisms, Opportunities by Walsh

This is the PDF eBook version for Antibiotics – Challenges, Mechanisms, Opportunities by Christopher Walsh, Timothy Wencewicz

Table of Contents

Preface ix

Section I Challenged for Antibiotics 1

1 Antibiotics: Initial Concepts and Considerations 4

2 Major Classes of Antibiotics and Their Modes of Action 16

Section II Mechanism: Antibiotic Action by Bacterial Target Class 33

3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls 36

4 Antibiotics That Block Peptidoglycan Assembly and Integrity 68

5 Antibiotics That Disrupt Membrane Integrity 102

6 Antibiotics That Block Protein Synthesis 114

7 Antibiotics That Target DNA and RNA Information Transfer 148

8 Antibiotics That Block Biosynthesis of the DNA Building Block Deoxythymidylate 164

Section III Mechanism: Bacterial Resistance to Antibiotics 177

9 Bacterial Antibiotic Resistance: Overview 180

10 Antibiotic Resistance: Modification or Destruction of the Antibiotic 198

11 Antibiotic Resistance via Membrane Efflux Pumps 220

12 Resistance via Target Modification 230

13 Tuberculosis: A Formidable Challenge for Antibiotic Therapy 252

Section IV Mechanisms: Antibiotic Biosynthesis 273

14 Antibiotic Biosynthesis: Principles 276

15 Biosynthesis of Peptide Antibiotics 288

16 Biosynthesis of Polyketide Antibiotics 320

17 Biosynthesis of Oligosaccharide, Isoprenoid, and C-P Antibiotic Classes 344

Section V Opportunities 363

18 Underexploited Pathways and Targets for Antibiotics 366

19 Prospects for New Molecules and New Targets 398

References 421

Index 455