(eBook) From Molecular to Modular Tumor Therapy by Albrecht Reichle

This is the PDF eBook version for From Molecular to Modular Tumor Therapy – Tumors are Reconstructible Communicatively Evolving Systems by Albrecht Reichle

Table of Contents

Part I Therapy-Derived Systems Biology: A Pragmatic Communication Theory

1 Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients Albrecht Reichle 3

2 Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options Albrecht Reichle 9

3 Principles of Modular Tumor Therapy Albrecht Reichle Gerhard C. Hildebrandt 29

Part II Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies

4 Cancer and Coagulation; Focusing on Tissue Factor and Heparanase Yona Nadir 51

5 The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity Ofer Shoshani Dov Zipori 75

6 Shaping Tumor Associated Macrophages: The Role of NF-kB Robin Soper Thorsten Hagemann 97

7 The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target Eva Gottfried Katrin Peter Marina P. Kreutz 111

8 Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients? Oliver Grauer Peter Hau 133

Part III Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’

9 Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins Wendy Wing Shan Yeung Maurice Kwok Chung Ho Yung Hou Wong 161

10 Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-kB Ilse M.E. Beck Guy Haegeman Karolien De Bosscher 191

11 The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment Urban Emmenegger Annabelle Chow Guido Bocci 243

Part IV Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy

12 Systems Biology: A Therapeutic Target for Tumor Therapy Albrecht Reichle Thomas Vogt 265

13 The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation Albrecht Reichle Gerhard C. Hildebrandt 287

14 Searching for the ‘Metabolism’ of Evolution Albrecht Reichle Gerhard C. Hildebrand 305

Part V Biomodulatory Therapy Approaches in Metastatic Cancer

15 The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival Ulrika Smedh Annika Gustafsson Hans Axelsson Christian Cahlin Christina Lönnroth Kent Lundholm 313

16 Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma Albrecht Reichle Frank Klebl Klaus Bross Frank Kullmann Peter Wild Anna Berand Stefan W. Krause Jürgen Schölmerich Reinhard Andreesen 341

17 C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma Bernhard Walter Irmela Schrettenbrunner Martin Vogelhuber Jochen Grassinger Klaus Bross Jochen Wilke Thomas Suedhoff Anna Berand Wolf-Ferdinand Wieland Sebastian Rogenhofer Albrecht Reichle 353

18 Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer Bernhard Walter Sebastian Rogenhofer Martin Vogelhuber Jochen Wilke Anna Berand Walter Ferdinand Wieland Reinhard Andreesen Albrecht Reichle 367

19 Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP) Albrecht Reichle Martin Vogelhuber Anna Berand Reinhard Andreesen Irene Fackler-Schwalbe Annemarie Rübel Thomas Südhoff 379

Part VI Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging

20 Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis Fabian Kiessling Wiltrud Lederle 385

21 Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches Verena Paulitschke Rainer Kunstfeld Christopher Gerner 405

22 Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma Stefanie Meyer Thomas Vogt Michael Landthaler Anna Berand Albrecht Reichle Frauke Bataille Andreas Marx Guido Sauter Arndt Hartmann Leoni Kunz-Schughart Peter J. Wild 433

Part VII Pharmacological Considerations on Systems Biological Therapy Approaches

23 Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies Albrecht Reichle 469

24 Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy Annika Bundscherer Christian Hafner 483

Part VIII Tumors’ Systems Biology: Implications for Personalized Therapy

25 A Methodological Approach to Personalized Therapies in Metastatic Cancer Albrecht Reichle Thomas Vogt Gerhard C. Hildebrandt 507

Part IX Summary

26 To Be an Object in a Biological System: The Necessity of a Formal-Pragmatic Communication Theory Albrecht Reichle Gerhard C. Hildebrandt 537

27 From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy Albrecht Reichle Gerhard C. Hildebrandt 545

Index 557