(eBook) Development of Antibody-Based Therapeutics 2nd Edition by Tabrizi

This is the PDF eBook version for Development of Antibody-Based Therapeutics – Translational Considerations & Challenges 2nd Edition by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp

Table of Contents

1. Introduction.- 2. Translational Considerations and Challenges: An Overview.- 3. Considerations for Construct and Affinity Design Goals.- 4. Epitope Characterization and Isotype Selection.- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics.- 6. Novel Technologies for Generation of Bispecific Constructs.- 7. Stimulus-Response Mechanisms: An Overview.- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models –A Quantitative Approach.- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities.- 10. Antibody Drug Conjugates: Translational Considerations.- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs.- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.